Study Of Serum Hs-C Reactive Protein And Serum Uric Acid In Type-II Diabetic Patients

Abstract

A complex metabolic condition, diabetes affects the body's glucose level in several ways. Hyperglycemia and impaired glucose tolerance are the hallmarks of type 2 diabetes, which may be caused by either a relative or total lack of insulin or a resistance to its effects. End organ malfunction and failure may occur as a consequence of chronic hyperglycemia in people with diabetes. This can happen to the retina, kidneys, nerves, heart, and blood vessels. Patients with diabetes have a substantially increased risk for cardiovascular disease (CVD), and there is strong clinical evidence linking diabetes to atherosclerotic cardiovascular disease. Among the many factors that contribute to the development and advancement of accelerated atherosclerosis in people who have type 2 diabetes mellitus, inflammation is a key player. Therefore, new biomarkers of inflammation, such as high-sensitivity C-reactive protein, may be used to predict the likelihood of cardiovascular disease. A variety of morbidity statuses, such as hypertension, metabolic syndrome, renal illness, and cardiovascular disease, are linked to hyperuricemia. The current research aims to assess the serum uric acid and high sensitivity C reactive protein levels in individuals with type 2 diabetes.
In order to measure the concentrations of high-sensitivity C-reactive protein in individuals with type 2 diabetes. In order to measure the serum uric acid levels in individuals with type 2 diabetes and If there is a relationship between hs-CRP and serum uric acid, we want to know about it. Seventy healthy individuals and seventy people with type 2 diabetes were among the 140 people who participated in the study. The immunoturbidimetry was used to evaluate the amounts of uric acid and high-sensitivity C-reactive protein (hs-CRP) in the serum. The statistical study was conducted using Spearman's Rank Correlation and an independent Students' t-test.
There was no significant link between hs-CRP and Uric acid, although there was a substantial rise in both serum uric acid levels and high-sensitivity C-reactive protein (p <0.001) in type 2 diabetes participants compared to controls.
Researchers discovered that high-sensitivity C-reactive protein levels were significantly higher in those with type 2 diabetes compared to healthy controls. Glycated haemoglobin, high-sensitivity C-reactive protein, and fasting serum glucose are strongly correlated. Patients with type 2 diabetes had significantly higher blood uric acid levels than non-diabetic controls, according to our research. Additionally, hs-CRP and uric acid did not correlate significantly. Patients with type 2 diabetes mellitus are at increased risk for complications and disease-related morbidity due in large part to serum uric acid levels. In individuals with type 2 diabetes, elevated levels of hs-CRP and serum uric acid indicate the likelihood of future cardiovascular problems.