Histological Correlation Of All Palpable Breast Lumps Using Fine Needle Aspiration Cytology

Abstract

Breast is a dynamic structure that changes throughout the reproductive life and menstruation cycles. Breast lumps are a common issue among females, and various diseases are prevalent in both developed and developing countries. A prospective study of cytology and histopathology was conducted in the Central lab and the Department of Pathology, involving 100 cases from January 2020-December 2022. The majority of the patients were between 21-40 years old and presented with a mass in the breast, with most in the left breast. FNAC was classified into C1-C5 categories, with 76 cases being benign. The C5 category included 15 cases of duct carcinoma-NOS type, 2 cases of mucinous carcinoma, and a case each of lobular carcinoma and malignant phyllodes. FNAC was found to be 90% sensitive, 98.75% specific, and 97% accurate in the diagnosis of malignant lesions, with a false negative percentage of 10%. This study suggests that FNAC is an effective and valid tool for preoperative diagnosis of both benign and malignant lesions. When combined with physical examination, mammography, and FNAC, the results show high sensitivity, specificity, positive and negative predictive value, leading to reliable early breast cancer diagnosis.